Dr family Bacterial adhesin

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the dr family of adhesins bind dr blood group antigen component of decay-accelerating factor (daf). these proteins contain both fimbriated , afimbriated adherence structures , mediate adherence of uropathogenic escherichia coli urinary tract. inducing development of long cellular extensions wrap around bacteria. confer mannose-resistant hemaglutination phenotype, can inhibited chloramphenicol. n-terminal portion of mature protein thought responsible chloramphenicol sensitivity. also, induce activation of several signal transduction cascades, including activation of pi-3 kinase.


the dr family of adhesins particularly associated cystitis , pregnancy-associated pyelonephritis.


multivalent adhesion molecules


multivalent adhesion molecules (mams) widespread family of adhesins found in gram negative bacteria, including e. coli, vibrio, yersinia, , pseudomonas aeruginosa. mams contain tandem repeats of mammalian cell entry (mce) domains bind extracellular matrix proteins , anionic lipids on host tissues. since abundant in many pathogens of clinical importance, multivalent adhesion molecules potential target prophylactic or therapeutic anti-infectives. use of mam targeting adhesion inhibitor shown decrease colonization of burn wounds multidrug resistant pseudomonas aeruginosa in rats.








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