Pathology Ganglioside

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a summary showing causes of sphingolipidosis, including gangliosidosis.



gangliosides involved in several diseases:



influenza, in haemagglutinin of influenza virus exploits gangliosides enter , infect cells expressing them.
guillain–barré syndrome, has been linked production of anti-ganglioside antibodies.
cholera
tetanus
botulism
leprosy
obesity, inadequate ganglioside expression in mediobasal hypothalamic neurons deregulates neuronal leptin , insulin signaling.




^ lubert stryer (1975). biosynthesis of macromolecular precursors . biochemsitry. w h freeman & co. p. 486. isbn 0-7167-0174-x. 
^ nachamkin i; shadomy, sv; moran, ap; cox, n; fitzgerald, c; ung, h; corcoran, at; iskander, jk; et al. (2008). anti-ganglioside antibody induction swine (a/nj/1976/h1n1) , other influenza vaccines: insights vaccine-associated guillain–barré syndrome . j. infect. dis. 198 (2): 226–33. doi:10.1086/589624. pmid 18522505. 
^ ribeiro-resende, vt; ribeiro-guimarães, ml; lemes, rm; nascimento, ic; alves, l; mendez-otero, r; pessolani, mc; lara, fa (29 oct 2010). involvement of 9-o-acetyl gd3 ganglioside in mycobacterium leprae infection of schwann cells . journal of biological chemistry. american society of biochemistry , molecular biology. 285 (44): 34086–34096. doi:10.1074/jbc.m110.147272. pmc 2962507 . pmid 20739294. retrieved 15 april 2016. 
^ nordström v., willershäuser m., herzer s., rozman j., von bohlen und halbach o., meldner s.; et al. (march 12, 2013). neuronal expression of glucosylceramide synthase in central nervous system regulates body weight , energy homeostasis . plos biology. 11 (3): e1001506. doi:10.1371/journal.pbio.1001506. pmc 3595213 . pmid 23554574. cs1 maint: explicit use of et al. (link) cs1 maint: multiple names: authors list (link)
^ herzer, silke; meldner, sascha; gröne, hermann-josef; nordström, viola (2015-10-01). fasting-induced lipolysis , hypothalamic insulin signaling regulated neuronal glucosylceramide synthase (pdf). diabetes. 64 (10): 3363–3376. doi:10.2337/db14-1726 . issn 0012-1797. pmid 26038579. 






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